Our bioprospecting efforts are directed at understanding the true biosynthetic potential of marine invertebrates (sponges, tunicates), fish, macrophytes as well their associated microbiota for discovery of bioactive secondary metabolites for potential development. We address global health challenges, by focusing on e.g., cancer, and pathogens causing diseases in human, crops, food or aquaculture. Macroorganisms will be extracted automatically using green extraction techniques, such as ASE and SFE. When working with microorganisms (bacteria and fungi), we apply innovative techniques to i) increase their cultivability in laboratory conditions, and ii) activate their silent biosynthetic gene clusters (e.g., by co-cultivation) to produce new metabolites. Any organism with high bioactivity and novel chemistry will be submitted to discovery pipeline for purification (HPLC and others) and 3D chemical characterization (NMR, MS and other spectroscopic techniques) of new molecules. Purification of target (new) compounds is monitored by MS-based metabolomics, bioinformatics and bioassays. We are also interested in valorization of waste material.
Selected publications:
Oppong-Danquah, E. , Miranda, M., 叠濒眉尘别濒, M., Tasdemir, D. (2023) Marine Drugs, 21 (2). Art.Nr. 129. DOI .
Magot, F., Van Soen, G., Buedenbender, L., Li, F., Soltwedel, T., Grauso, L., Mangoni, A., 叠濒眉尘别濒, M. und Tasdemir, D. (2023) Marine Drugs, 21 (2). Art.Nr. 95. DOI .
Vitale, G. A., January, G. G., Oppong-Danquah, E. , Della Sala, G., Palma Esposito, F., Tasdemir, D. und de Pascale, D. (2023) PNAS Nexus, 2 (7). Art.Nr. pgad221. DOI .
Eroldo臒an, O. T., Glencross, B., Novoveska, L., Gaud锚ncio, S. P., Rinkevich, B., Varese, G. C., de F谩tima Carvalho, M., Tasdemir, D. , Safarik, I., Nielsen, S. L., Rebours, C., Lada, L. B., Robbens, J., Strode, E., Haznedaro臒lu, B. Z., Kotta, J., Evliyao臒lu, E., Oliveira, J., Gir茫o, M., Vasquez, M. I., 膶abarkapa, I., Rakita, S., Klun, K. und Rotter, A. (2023) Reviews in Aquaculture, 15 (3). pp. 1028-1057. DOI .
Freitas, S., Castelo-Branco, R., Wenzel-Storjohann, A., Vasconcelos, V. M., Tasdemir, D. und Le茫o, P. N. (2022) Journal of Natural Products, 85 (7). pp. 1704-1714. DOI .
Ghotbi, M., Kelting, O., 叠濒眉尘别濒, M. und Tasdemir, D. (2022) Marine Drugs, 20 (9). Art.Nr. 573. DOI .
Oppong-Danquah, E., 叠濒眉尘别濒, M., Scarpato, S., Mangoni, A. und Tasdemir, D. (2022) International Journal of Molecular Sciences, 23 (2). Art.Nr. 782. DOI .
Rudovica, V., Rotter, A., Gaud锚ncio, S. P., Novovesk谩, L., Akg眉l, F., Akslen-Hoel, L. K., Alexandrino, D. A. M., Anne, O., Arbidans, L., Atanassova, M., Be艂dowska, M., Be艂dowski, J., Bhatnagar, A., Bikovens, O., Bisters, V., Carvalho, M. F., Catal谩, T. S., Dubnika, A., Erdo臒an, A., Ferrans, L., Haznedaroglu, B. Z., Setyobudi, R. H., Graca, B., Grinfelde, I., Hogland, W., Ioannou, E., Jani, Y., Katar啪yt臈, M., Kikionis, S., Klun, K., Kotta, J., Kriipsalu, M., Labidi, J., Luki膰 Bilela, L., Mart铆nez-Sanz, M., Oliveira, J., Ozola-Davidane, R., Pilecka-Ulcugaceva, J., Pospiskova, K., Rebours, C., Roussis, V., L贸pez-Rubio, A., Safarik, I., Schmieder, F., Stankevica, K., Tamm, T., Tasdemir, D. , Torres, C., Varese, G. C., Vincevica-Gaile, Z., Zekker, I. und Burlakovs, J. (2021) Frontiers in Marine Science, 8. Art.Nr. 723333. DOI .
Di, X. , Wang, S., Oskarsson, J. T., Rouger, C., Tasdemir, D. , Hardardottir, I., Freysdottir, J., Wang, X. , Molinski, T. F. und Omarsdottir, S. (2020) Journal of Natural Products, 83 (10). pp. 2854-2866. DOI .
Li, F. , Pandey, P. , Janussen, D. , Chittiboyina, A. G. , Ferreira, D. und Tasdemir, D. (2020) Journal of Natural Products, 83 (3). pp. 706-713. DOI .
Oppong-Danquah, E., Budnicka, P., 叠濒眉尘别濒, M. und Tasdemir, D. (2020) Marine Drugs, 18 (2). Art.Nr. 73. DOI .
Oppong-Danquah, E., Parrot, D., 叠濒眉尘别濒, M., Labes, A. und Tasdemir, D. (2018) Frontiers in Microbiology, 9 . Art.Nr. 2072. DOI .
Chianese, G., Silber, J., Luciano, P., Merten, C., Erpenbeck, D., Topaloglu, B., Kaiser, M. und Tasdemir, D. (2017) Journal of Natural Products, 80 (9). pp. 2566-2571. DOI .
