We use tandem (MS/MS) mass spectrometry-based high throughput computational untargeted metabolomics, particularly the Feature-Based Molecular Networking workflow for detailed identification of chemical inventories of marine macro- and microorganisms. Combined with additional bioinformatics tools, these algorithm-based metabolomics can also assist prediction of chemical structures and bioactivity of marine molecules. Comparative metabolomics data (integrated with biological activity) is crucial for prioritization of the most promising samples for chemical work-up, and for monitoring the entire purification process to discover ecologically or biologically active molecules in a targeted manner.
Through exometabolomics/environmental metabolomics approach, we identify, directly, ecologically relevant allelochemicals exuded into seawater to modulate species interactions.
Spatial metabolomics (by DESI Imaging Mass Spectrometry, DESI-IMS), allows us to localize metabolites on biological surfaces and inner tissues, thus delivering information on their site of biosynthesis and potential ecological functions.
Metabolomic analyses are supported by statistical, machine learning and chemometrics tools.
Selected publications:
Tasdemir, D., Scarpato, S., Utermann, C., Jensen, T., Bl眉mel, M., Wenzel-Storjohann, A., Welsch, C. und Echelmeyer, V. A. (2024) Science of the Total Environment, 908 . Art.Nr. 168422. DOI .
Vitale, G. A., January, G. G., Oppong-Danquah, E. , Della Sala, G., Palma Esposito, F., Tasdemir, D. und de Pascale, D. (2023) PNAS Nexus, 2 (7). Art.Nr. pgad221. DOI .
Fan, B., Grauso, L., Li, F., Scarpato, S., Mangoni, A. und Tasdemir, D. (2022) Marine Drugs, 20 (3). Art.Nr. 210. DOI .
Hassani, M. A., Oppong-Danquah, E., Feurtey, A., Tasdemir, D., Stukenbrock, E. H. und Druzhinina, I. S. (2022) Applied and Environmental Microbiology, 88 (6). Art.Nr. e02296-21. DOI .
Xu, M., Oppong-Danquah, E. , Wang, X., Oddsson, S., Abdelrahman, A., Pedersen, S. V., Szomek, M., Gylfason, A. E., Snorradottir, B. S., Christensen, E. A., Tasdemir, D., Jameson, C. J., Murad, S., Andresson, O. S., Magnusson, K. P., de Boer, H. J., Thorsteinsdottir, M., Omarsdottir, S., Heidmarsson, S. und Olafsdottir, E. S. (2022) Phytochemistry, 200. Art.NR. 113210. DOI .
Buedenbender, L. , Kumar, A., Bl眉mel, M. , Kempken, F. und Tasdemir, D. (2021) Marine Drugs, 19 (1). Art.Nr. 14. DOI .
Utermann, C., Bl眉mel, M., Busch, K., Buedenbender, L., Lin, Y., Haltli, B. A., Kerr, R. G., Briski, E., Hentschel, U. und Tasdemir, D. (2020) Microorganisms, 8 (12). Art.Nr. 2022. DOI .
Papazian, S., Parrot, D., Bur媒拧kov谩, B., Weinberger, F. und Tasdemir, D. (2019) Scientific Reports, 9 (1). Art.Nr. 3323 (2019). DOI .
Parrot, D., Bl眉mel, M., Utermann, C., Chianese, G., Krause, S., Kovalev, A. , Gorb, S. und Tasdemir, D. (2019) Scientific Reports, 9 (1061). DOI .
Parrot, D., Papazian, S., Foil, D. und Tasdemir, D. (2018) Planta Medica, 84 (09/10). pp. 584-593. DOI .
